• About Us
  • Advertise
  • Contact Us
  • DMCA
  • Privacy Policy
  • Follow on Google News
Friday, March 31, 2023
  • Login
Country First
  • Home
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
    • Gadgets
  • Auto
  • Others
    • Sports
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
  • Home
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
    • Gadgets
  • Auto
  • Others
    • Sports
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
Country First
No Result
View All Result

Researchers reveal how excess sugar causes fatty liver

Country First by Country First
June 18, 2021
in Health & Fitness
Reading Time: 3 mins read
A A
0
Share on FacebookShare on Twitter

New Delhi: In a new study conducted by the researchers at Indian Institute of Technology (IIT), Mandi has conclusively shown that excessive sugar intake leads to a fatty liver. This could offer an incentive for reducing sugar intake to stop non-alcoholic fatty liver disease (NAFLD) in its early stages. The unravelling of the molecular link between sugar and fat accumulation in liver is key to developing therapeutics for the disease, researchers said.

A team of researchers from IIT Mandi, led by Dr Prosenjit Mondal, Associate Professor, School of Basic Sciences, has used complementary experimental approaches to establish the underlying biochemical relationship between the consumption of excessive sugar and the development of ‘fatty liver’, medically known as Non-Alcoholic Fatty Liver Disease (NAFLD). This research comes at a time in which the Government of India has included NAFLD in the National Programme for Prevention & Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS).

You might also like

Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services

Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services

March 20, 2023
Do rare Diseases account for the economic burden on India?

Do rare Diseases account for the economic burden on India?

March 20, 2023

NAFLD is a medical condition in which excess fat deposits in the liver. The disease starts silently, with no overt symptoms for as much as two decades. If left untreated, the excess fat can irritate the liver cells, resulting in scarring of the liver (cirrhosis), and in advanced cases, can even lead to liver cancer. The treatment of advanced stages of NAFLD is difficult.

Dr Prosenjit Mondal said, “The molecular mechanisms that increase hepatic DNL due to overconsumption of sugar have not been clear.” “Our goal was to unravel this mechanistic pathway between excessive sugar consumption and onset and development of fatty liver Through DNL”, he further added.

India is the first country in the world to identify the need for action on NAFLD and with good reason. The prevalence of NAFLD in India is about 9% to 32% of the population, with the state of Kerala alone having a prevalence of 49% and a staggering 60% prevalence among obese school-going children.

One of the causes for NAFLD is the over-consumption of sugar – both table sugar (sucrose) and other forms of carbohydrates. The consumption of excess sugar and carbohydrates causes the liver to convert them into fat in a process called hepatic De Novo Lipogenesis or DNL, which leads to fat accumulation in the liver.

Through a complementary experimental approach involving mice models, the IIT Mandi team has shown the hitherto unknown link between the carbohydrate-induced activation of a protein complex called NF-κB and increased DNL.

“Our data indicates that the sugar-mediated shuttling of hepatic NF-κB p65 reduces the levels of another protein, sorcin, which in turn activates liver DNL through a cascading biochemical pathway,” explained the lead scientist.

The research team has shown that drugs that can inhibit NF-κB can prevent sugar-induced hepatic fat accumulation. They have also shown that the knockdown of sorcin reduces the lipid-lowering ability of the NF-κB inhibitor.

This study shows that NAFLD can now be added to the repertoire of diseases that can be treated with drugs that block NF-κB. NF-κB also plays a role in other diseases that involve inflammation, such as cancer, Alzheimer’s disease, atherosclerosis, IBS, stroke, muscle wasting and infections, and scientists around the world are developing therapeutics that can block NF-κB, IIT Mandi Statement said.

This study has been published in the Journal of Biological Chemistry. The research paper has been co-authored by Dr Prosenjit Mondal along with his research scholars, Mr. Vineeth Daniel, Ms. Surbhi Dogra, Ms. Priya Rawat, Mr. Abhinav Choubey from IIT Mandi, in collaboration with Dr Mohan Kamthan and Ms. Aiysha Siddiq Khan from Jamia Hamdard Institute, New Delhi, along with Mr. Sangam Rajak from SGPGI, Lucknow. (India Science Wire)

Tags: Fatty LiverIIT MandiIndian Institute of TechnologyKeywords: Sugar IntakemolecularNAFLDNon-alcoholic fatty liver disease
Previous Post

Older adults are at higher risk of social isolation during COVID pandemic: Study

Next Post

TTK Prestige Ltd launches a new e-commerce enabled website for its second brand “JUDGE” in India 

Country First

Country First

Related Posts

Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services

Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services

by Country First
March 20, 2023
0

To provide End-to-End Linen Management Services in India Bangalore (Karnataka) : Toyota Tsusho, a renowned global trading company within the...

Do rare Diseases account for the economic burden on India?

Do rare Diseases account for the economic burden on India?

by Country First
March 20, 2023
0

The meaning of the term "Rare" is "not occur very often", but rare diseases are cumulatively not so rare anymore....

zPlus.care for all your healthcare needs

zPlus.care for all your healthcare needs

by Country First
March 17, 2023
0

zPlus.Care, where monthly shopping, bill payments pay for your health care. Health insurance should be every Indian’s priority but in...

YOGA - A blessing for feminine fitness by Heena Rajgor

YOGA – A blessing for feminine fitness by Heena Rajgor

by Country First
March 9, 2023
0

Yoga is an effective workout that can be easily practiced from home or anywhere, do not even need any instruments....

Next Post

TTK Prestige Ltd launches a new e-commerce enabled website for its second brand “JUDGE” in India 

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Related Post

National Coach for Muay Thai India Balkrishan Shetty applauds Ramagya Sports Academy for world-class infrastructure

September 22, 2021
Deshpremi Rishi- Renowned Orrisa Activist receives Honorary Doctorate Award for Social Work and humanitarian services

Deshpremi Rishi- Renowned Orrisa Activist receives Honorary Doctorate Award for Social Work and humanitarian services

November 5, 2022

Remarkable Inter-School Debate Competition hosted by G.D. Goenka International School, Surat

December 24, 2020

Category

  • Agriculture
  • App News
  • Astrology
  • Auto
  • Business
  • Education
  • Entertainment
  • Fashion & Beauty
  • Finance/Money
  • Food
  • Gadgets
  • Health & Fitness
  • Lifestyle
  • National
  • Photography
  • Politics
  • Press Release
  • Religion
  • Science
  • Social Work
  • Sports
  • State News
  • Tech
  • Travel
  • World

Tags

Ace Entrepreneur Ahmedabad Artificial intelligence Bengaluru Blockchain technology Content Creator COVID-19 Cryptocurrency CSIR DBT DeFi and NFT navigation tool Delhi DeSpace Protocol Digital Marketing disease DST Dubai Education entrepreneur environment Ginny Kapoor Gujarat India's Most Prominent Pageant Indian Institute of Technology Influencer Influencerquipo Kingston Technology MoES Mr. Gagandeep Kapoor Mrs.INDIA Galaxy Mrs.INDIA Galaxy 2022 Mumbai Music Industry National Pageant Mrs.INDIA Galaxy 2022 NFT pandemic photography real estate research science social media Surat technology TTK Prestige Vibrant Concepts

Country First is a digital news and story platform that bring you the news, articles, stories, and opinions on the latest happenings worldwide covering various sectors like nation, politics, and governance, social sector, review, foreign affairs, defence and security, latest review, lifestyle, entertainment, sports, technology, auto sectors, education, business and start-ups updates, Agriculture, Science, finance, money, food, and culture, etc.

  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Privacy Policy
  • Follow on Google News

© 2022 Country First

No Result
View All Result
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Home
  • Privacy Policy

© 2022 Country First

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In