• About Us
  • Advertise
  • Contact Us
  • DMCA
  • Privacy Policy
  • Follow on Google News
Tuesday, June 6, 2023
  • Login
Country First
  • Home
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
    • Gadgets
  • Auto
  • Others
    • Sports
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
  • Home
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
    • Gadgets
  • Auto
  • Others
    • Sports
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
Country First
No Result
View All Result

New hope for mitochondrial disorders

Country First by Country First
March 31, 2021
in Health & Fitness, Science
Reading Time: 2 mins read
A A
0
Share on FacebookShare on Twitter

New Delhi: Efforts to find a treatment for mitochondrial disorders is set to get a major boost with a team of researchers at the Department of Biotechnology’s National Institute of Immunology (DBT-NII) figuring out a way to tackle autosomal dominant progressive external ophthalmoplegia (adPEO), which is a widely prevalent mitochondrial disorder.

Mitochondrial genetic disorders refer to a group of conditions that affect the mitochondria, the structures in the body cells that are responsible for making energy. People with these conditions can be of any age with almost any affected body system. However, the brain, muscles, heart, liver, nerves, eyes, ears and kidneys are the organs and tissues most commonly affected. Symptom severity can also vary widely.

You might also like

Narayana Health welcomes Internationally Acclaimed Orthopedic, Spine and Trauma Expert, Professor (Dr) Arun Ranganathan

Narayana Health welcomes Internationally Acclaimed Orthopedic, Spine and Trauma Expert, Professor (Dr) Arun Ranganathan

May 18, 2023
SAKRA World Hospital launches the SAKRA Information Centre in Bardhaman, West Bengal

SAKRA World Hospital launches the SAKRA Information Centre in Bardhaman, West Bengal

May 9, 2023

Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy. Those caused by mutations in mitochondrial DNA are transmitted by maternal inheritance, while those caused by mutations in nuclear DNA may follow an autosomal dominant, autosomal recessive or X-linked pattern of inheritance. Treatment varies based on the specific type of condition and the signs and symptoms present in each person.

In the new study, the researchers at NII focused on autosomal dominant progressive external ophthalmoplegia (adPEO) as it is one of the most common Mitochondrial disorders. The disorder occurs when there is a problem in the replication and removal of mismatches in the mitochondrial DNA. In healthy mitochondria, a protein called Polymerase Gamma carries out these two vital functions. It consists of a single catalytic subunit, Polymerase GammaA, which complexes with two identical subunits of the accessory factor, Polymerase GammaB. Polymerase Gamma has to move inside the mitochondria to do its work.

So far, the dogma was that the transport into mitochondria was determined by a peptide called Mitochondrial Localization Signal (MLS). The new study has extended the present knowledge. The researchers have found that along with MLS, a process called ubiquitylation, also decides whether Polymerase Gamma A will optimally enter the mitochondria. The study also zeroed in on another protein called MITOL, which is present on the outer membrane of the mitochondria, was behind the ubiquitylation of Polymerase GammaA.  The team also determined the site on the Polymerase GammaA that gets ubiquitylated by MITOL.

On further study, the researchers found that Polymerase GammaA in 50% of the tested adPEO patients was highly ubiquitylated. However it was possible to reverse the process of ubiquitylation either by removing MITOL itself or by genetically modifying the site Polymerase GammaA in adPEO patients that gets highly ubiquitylated by MITOL. Speaking to India Science Wire, the leader of the team, Dr. SagarSengupta, said, “It will be interesting to test in future whether the reactivation of Polymerase Gamma A can actually be carried out in the patients using mitochondrial genome editing techniques”.

The research findings have been published in the journal PLoS Biology. The research team includes Mansoor Hussain, Aftab Mohammed, ShabnamSaifi, Aamir Khan, Ekjot Kaur, Swati, Priya and Himanshi Agarwal, besides Dr. Sengupta. (India Science Wire)

Tags: autosomalbrainDBTDBT-NIIDepartment of BiotechnologyDNAearenergyeyegenome editingheartkidneylivermaternal inheritancemismatchmusclesmutationNational Institute of Immunologynerveorganreplicationsymptomtissuetreatment
Previous Post

Cord Blood transplant outperforms bone marrow transplant states a new study by ASH

Next Post

Salt substitution is effective to reduce blood pressure in rural India

Country First

Country First

Related Posts

Narayana Health welcomes Internationally Acclaimed Orthopedic, Spine and Trauma Expert, Professor (Dr) Arun Ranganathan

Narayana Health welcomes Internationally Acclaimed Orthopedic, Spine and Trauma Expert, Professor (Dr) Arun Ranganathan

by Country First
May 18, 2023
0

Bangalore (Karnataka) : India’s leading healthcare provider, Narayana Health, has announced the appointment of globally renowned orthopedic & spine specialist...

SAKRA World Hospital launches the SAKRA Information Centre in Bardhaman, West Bengal

SAKRA World Hospital launches the SAKRA Information Centre in Bardhaman, West Bengal

by Country First
May 9, 2023
0

Kolkata (West Bengal) : The SAKRA World Hospital in Bangalore is a premier healthcare organization, with Japanese processes and know...

Sharp Sight goes above and beyond for employees with ESOP offering

Sharp Sight goes above and beyond for employees with ESOP offering

by Country First
April 25, 2023
0

New Delhi: Sharp Sight Eye Hospitals has rolled out an employee share benefit scheme, offering around 3.98% of its equity...

P&G Health collaborates with the Indian Medical Association, launches VitaM.I.N.D.S conclave

P&G Health collaborates with the Indian Medical Association, launches VitaM.I.N.D.S conclave

by Country First
April 18, 2023
0

This unique program will focus on increasing awareness around nutritional deficiencies and build advocacy of VMS supplements amongst healthcare professionals...

Next Post

Salt substitution is effective to reduce blood pressure in rural India

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Related Post

Scientists develop low-cost biodegradable wound dressing film

August 12, 2021
A comprehensive course that will teach you everything you need to know about finance and investing

A comprehensive course that will teach you everything you need to know about finance and investing

October 7, 2022

Inter-sectorial Convergence for COVID 19 vaccination

January 20, 2021

Category

  • Agriculture
  • App News
  • Astrology
  • Auto
  • Business
  • Education
  • Entertainment
  • Fashion & Beauty
  • Finance/Money
  • Food
  • Gadgets
  • Health & Fitness
  • Lifestyle
  • National
  • Photography
  • Politics
  • Press Release
  • Religion
  • Science
  • Social Work
  • Sports
  • State News
  • Tech
  • Travel
  • World

Tags

Ace Entrepreneur Ahmedabad Artificial intelligence Bengaluru Blockchain technology Content Creator COVID-19 CSIR DBT Delhi DeSpace Protocol Digital Marketing DST Dubai Education entrepreneur environment Fairplay Ginny Kapoor Gujarat Hyderabad India's Most Prominent Pageant Indian Institute of Technology Influencer Influencerquipo Kingston Technology K Raheja Corp Homes MoES Mr. Gagandeep Kapoor Mrs.INDIA Galaxy Mrs.INDIA Galaxy 2022 Mumbai Music Industry National Pageant Mrs.INDIA Galaxy 2022 NFT Noida pandemic photography Pune real estate research social media Surat TTK Prestige Vibrant Concepts

Country First is a digital news and story platform that bring you the news, articles, stories, and opinions on the latest happenings worldwide covering various sectors like nation, politics, and governance, social sector, review, foreign affairs, defence and security, latest review, lifestyle, entertainment, sports, technology, auto sectors, education, business and start-ups updates, Agriculture, Science, finance, money, food, and culture, etc.

  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Privacy Policy
  • Follow on Google News

© 2022 Country First

No Result
View All Result
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Home
  • Privacy Policy

© 2022 Country First

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In